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学术报告:聚集诱导发光探针在生物及医学上的应用
作者:教师   编辑: 教师   日期:2017-05-09     点击数:261  
 

时间:2017523日星期二,上午10:30

地点:材料先进技术教育部重点实验室215

唐友宏博士

澳大利亚福林德斯大学纳米科技中心与医疗器械研究所研究主任

Abstract

A photophysical phenomenon associated with chromogen aggregation is aggregation-induced emission (AIE), which is opposite to the ubiquitous aggregation-caused quenching phenomenon, a common to most aromatic hydrocarbons and their derivatives. In the AIE process, weakly luminescent chromogens are induced to emit efficiently by the aggregate/restriction formation. The restriction of intramolecular motion processes mechanistically account for all the AIE systems developed so far.

A few cases of AIEgens for biological and medical applications, conducted in Flinders University recently have been highlighted. (1) Monitor α-synuclein fibrillation in Parkinson’s disease. An AIEgen, TPE-TPP, is utilized as a fluorescence probe to monitor the α- synuclein fibrillation process. Compared with ThT (the commercial probe), TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence, (2) Point-of-care of chronic kidney disease with smart phone devices. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. IDATPE and BSPOTPE are successfully developed for creatinine and human serum albumin (HSA) quantitation, respectively with high selectivity. 3D printed imaging house is attached to a smartphone for quantitatively analyses HSA & creatinine concentration in urine to get UACR is developed and (3) Mammalian cell cytoplasmic tracker. A water soluble AIEgen, BSPOTPE, is reported for specifically staining cytoplasm of healthy mammalian cells. Excellent co-staining performances with different commercial dyes are demonstrated and BSPOTPE shows much high photo-stability and excellent intracellular retention time which makes it a good candidate for live-cell cytoplasm tracking.

个人简介:

唐友宏博士现为澳大利亚福林德斯大学(Flinders University)高级讲师,纳米科技中心(Centre for NanoScale Science and Technology)与医疗器械研究所(Medical Device Research Institute)研究主任 (Research leader)。澳大利亚科研管理局优秀青年科学基金获得者(ARC-DECRA)。他于2007年在香港科技大学获得了博士学位后,在华南理工大学任副教授。他于2012年从悉尼大学(University of Sydney)先进材料技术中心(Centre for Advanced Materials Technologies)应聘到福林德斯大学。他的研究兴趣广泛,主要集中在聚合物纳米材料的结构-加工-性能关系;具有聚集诱导发光特性的生物材料、生物传感器和器件以及船用复合材料等方面。近5年共发表了SCI论文120余篇,共撰写了9个章节,并出版2本著作。已获得了澳大利亚科研管理局的4项基金资助。唐博士为美国职业项目管理专家(Project Management Professional),澳大利亚皇家化学协会特许会员(MRACI CChem)及英国皇家化学协会会员(MRSC)